High-Throughput Transcriptomics for Mechanism-Informed Mixture Risk Assessment of Perfluoroalkyl Substances Using Human Biomonitoring Data.
Widespread human exposure to mixtures of perfluoroalkyl substances (PFAS) presents a challenge for risk assessment, as toxicological data for many PFAS are limited and mixture risk assessment requires insight into their shared toxicological mechanisms. In this study, we reanalyzed publicly available high-throughput tra...