Deciphering the Material Basis of an Herbal Formula via Integrated Two-dimensional Chromatography, In Silico Screening, and Comparative Pharmacokinetics: A Case Study of Kaiyu Jiangzhuo Formula
Kaiyu Jiangzhuo (KYJZ) is a Chinese medicine formula composed of nine herbs. Its efficacy in alleviating glycolipid metabolic disorders and reducing the incidence of diabetes mellitus in overweight patients with prediabetes has been widely validated. Although our previous studies separately characterized the chemical...