It is proposed that the therapeutic value of TREM2 is best understood through the concept of therapeutic window, and soluble TREM2 (sTREM2) should be interpreted cautiously, as it may reflect receptor shedding, target engagement, microglial state, disease stage, or a combination of these processes rather than serving a...
Qi-Xia Kuang, Shu-Jun Li, Wen-Di Huang et al.· Frontiers in Aging Neuroscie...· 0 citations
Three synergistic mechanisms by which peripherally administered MSCs may influence CNS disease outcomes are summarized, including homing, paracrine signaling, and immunomodulation.
Fang Chen, Ying Ge, Li Zhang et al.· Ageing Research Reviews· 0 citations
Key features of mitochondrial homeostasis in neurons are outlined, neuropathological and clinical data supporting the relevance of TDP-43 in AD are reviewed, and emerging mechanisms by which TDP-43 may perturb mitochondrial homeostasis are synthesized.
Wendi Huang, Juan Huang, Nan-Yu Kuang et al.· Ageing Research Reviews· 3 citations
Genomic manipulation has advanced from stochastic nuclease‐mediated disruption toward programmable, deterministic precision. Early clustered regularly interspaced short palindromic repeats (CRISPR) strategies enabled targeted mutagenesis through double‐strand breaks; however, their therapeutic application is limited by...
