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Open access Sep 2026

Cross-protective human antibodies against the Mpox virus discovered through structure-guided screening

Mpox virus (MPXV) poses an increasing global health threat, as underscored by two World Health Organization declarations of Public Health Emergencies of International Concern, particularly after the emergence of a novel Clade Ib strain that exhibited high human-to-human transmissibility in the Democratic Republic of th...

Dongdong Sun, Zi-Han Jia, Hongyu Han et al. · 0 citations
Open access Aug 2026

De Novo Design of a Protein Binder to Probe Gas Channel and Enhance the Oxygen Tolerance of [NiFe]-Hydrogenase.

[NiFe]-Hydrogenases display remarkable catalytic efficiency for H2 production and oxidation but are sensitive to O2, which severely restricts their biotechnological applications. The identities and functional relevance of gas channels leading to the buried [NiFe] active site remain elusive, hindering rational enzyme en...

Xuan Sun, Qi Xiao, Nan Zhang et al. · 0 citations

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