Nanan Landry Frejus

Molecular hybridization strategy for the design of benzimidazolyl-retrochalcone derivatives as antifungal agents: Synthesis, characterization, and CYP51-based computational evaluation

Abstract The growing resistance of Candida species highlights the need for antifungal agents targeting validated fungal enzymes. In this study, a series of benzimidazole-based retrochalcone derivatives was designed, and evaluated as potential inhibitors of lanosterol 14α-demethylase (CYP51). The design strategy combine...