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Author

Nanyan Miao

2 papers indexed here

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Open access Sep 2026

Adrenomedullin from spinal cord injury drives heterotopic ossification in skeletal muscle via a neuro–immune–bone axis

Neurological heterotopic ossification can rapidly arise in the periarticular muscles following spinal cord injury. However, the specific mechanism of how the injured central nervous system regulates heterotopic bone formation in peripheral tissues remains largely unexplored. Here we first demonstrate through single-cel...

Jie-Wen Chen, Zi-Long Wang, Xiao-Ling Zeng et al. · 0 citations
Jul 2026

Targeting tumor cell-intrinsic POU4F1 enhances antitumor immunity and sensitizes tumors to immunotherapy in basal-like breast cancer by modulating macrophage recruitment and polarization.

Mechanistic insights are provided into how POU4F1, a BLBC-specific transcription factor, orchestrates intercellular crosstalk to establish an immunosuppressive, tumor-supportive microenvironment, and indicate that targeting POU4F1 may represent a promising therapeutic strategy for BLBCs.

Jia-Hui Zhang, Nan-Yan Miao, Yun-Zhi Guo et al. · 0 citations

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