Oct 2026
Metabolic profile of thiopental and cytochrome P450-mediated drug interactions in rats.
1. Pentobarbital (PTB) is metabolised by cytochrome P450 (CYP) enzymes, being a model compound for evaluating CYP-mediated drug-drug interactions, has become difficult to obtain for animal studies in Japan. The metabolic pathway of thiopental (TP), a barbiturate with similar pharmacological properties, remains insuffic...
Tsukasa Kobayashi, Y. Takeba, Kouichi Sugaya et al.
· Xenobiotica; the fate of for... · 0 citations