Helicity Synchronization-Induced Kinetic Stabilization against Helix Inversion in Stapled Peptides: Effects of 310/α Block Sequence and Double-Stapling Topology
Communication between neighboring helical domains is central to biological function, yet dynamic interactions between distinct peptide helices remain poorly understood. Herein, we report a series of nonoverlapping doubly stapled block-type peptides composed entirely of achiral components and containing α-α, 310-310,...