Open access
Aug 2026
SARS-CoV-2 Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis to trigger lysosomal damage-mediated cell death
It is shown that variations in SARS-CoV-2 ORF3a correlate with the pathogenic potential of VOCs and drive Delta variant-specific lysosomal damage that activates inflammatory cell death and disrupts lysosomal homeostasis and triggers cell death.
Ayushi Amin Dey, Sanchita Mishra, Vigneshwar Reddy Ashireddygari et al.
· Communications Biology · 0 citations