Nario Tomishige

Impact of sphingomyelin species with different acyl chain lengths on plasma membrane organization.

The plasma membrane (PM) is characterized by asymmetric bilayer organization in terms of both the chemistry of lipid headgroups and the physical properties of lipid acyl chains. Sphingomyelin (SM), a major outer-leaflet lipid, has long been considered a key partner of cholesterol (Chol) in the formation of ordered memb...