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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Nasimul Hoda

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Open access Sep 2026

Targeting DYRK1A with rationally designed pyrazine–guanidine hybrids for Alzheimer's disease: design, synthesis, and biological evaluation

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been implicated in the pathogenesis of Alzheimer's disease (AD) by regulating tau hyperphosphorylation and neuroinflammatory pathways, suggesting DYRK1A as an important therapeutic target. Herein, we report the rational design, synthesis and eva...

Sabiha Khan, Sumaiya Khan, Shafa Khan et al. · 0 citations

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