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Author

Natacha Comandante-Lou

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Open access Sep 2026

BAG3 coordinates astrocytic proteostasis of Alzheimer's disease-linked proteins via proteasome, autophagy, and retromer interactions.

Bcl-2-associated athanogene 3 (BAG3) is a mediator of chaperone-assisted selective autophagy, and in the brain, is most highly expressed in astrocytes. However, its role in astrocytes remains poorly defined. Given the genetic and pathological links of BAG3 to proteostasis and neurodegenerative diseases, we investigated...

Zachary M. Augur, Garrett M. Fogo, Courtney R. Benoit et al. · 0 citations
Open access Aug 2026

Altered microglial communication in brains with Alzheimer’s Disease pathology

It was found that AD was characterized by altered microglial composition and rewiring of intercellular communication, including disease-specific signaling pathways and distinct interaction hubs.

Loren dos Santos, R. Vialle, Natacha Comandante-Lou et al. · 0 citations

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