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Natalia Rodríguez-Sosa

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Open access Aug 2026

Evolutionary rise of a synaptic mechanism for creating and diversifying key reinforcement signals

It is shown that GABA co-release is sufficient to produce temporal difference (TD)-like transformations of input activity, computations commonly used for reinforcement learning and behavioral optimization, and evolutionary expansion of glutamate/GABA co-release expanded across vertebrate evolution.

Natalia Rodríguez-Sosa, Lupita Rios, You-Hsin Lin et al. · bioRxiv · 0 citations