Open access
Dec 2025
Overcoming EGFR Resistance by Monovalent and Bident Inhibitors Targeting Cys775
This study establishes the therapeutic potential of an EGFR covalent inhibitor through unprecedented targeting of cysteine 775 and provides the first demonstration that dual cysteine engagement offers superior efficacy over conventional covalent inhibitors by delaying resistance.
Zheng-Nian Li, Jie Jiang, Ya-Ning Wang et al.
· bioRxiv · 1 citation