Antitumor activities of chimeric antigen receptor t cells targeting mucin-1 with self-secreting anti PD-1 IgG antibody
Chimeric antigen receptor (CAR) T cells have achieved notable success in treating hematological malignancies and are now being extensively studied as a strategy to overcome tumor immunosuppressive microenvironment in solid tumors. Mucin-1 (MUC1) is overexpressed in various solid tumors. CAR T cells targeting MUC1 have...