A novel series of seventeen carbazole–acrylamide–pyridinium-N-phenylacetamide hybrids (12a–q) was designed and synthesized as dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for potential Alzheimer's disease therapy. Their inhibitory activity was evaluated against both enzymes using tacr...
A. Taherkhani, Halil Şenol, Y. Valizadeh et al.· RSC Medicinal Chemistry· 0 citations
AIMS
In this study, new 2,3,4,9-tetrahydro-1H-carbazol-1,3,4-oxadiazole-N-phenylacetamide hybrids 8a-n as potential dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for the treatment of Alzheimer's disease (AD) were introduced.
METHODS
The target compounds were designed using a molecula...
A new series of compounds was evaluated as prospective in vitro antimalarial agents against the chloroquine‐sensitive 3D7 and chloroquine‐resistant K1 strains of Plasmodium falciparum, and the compound bearing a 4‐chloroaryl moiety was the most active against P. falciparum.
Lina Rezainia, M. Sayahi, Eisa Kaveh Vernousfaderani et al.· Chemistry and Biodiversity· 0 citations
Findings identify compound 9b as a promising lead α-glucosidase inhibitor with potent in vitro and in vivo antihyperglycemic activity, warranting further investigation for the treatment of type 2 diabetes.
Elika Salehi Ghalehsefid, Mohammad Halimi, Hassan Mohammadi et al.· European journal of medicina...· 0 citations
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