CRISPRi-Mediated Silencing of Efflux Pump Genes Restores Antibiotic Susceptibility in Multidrug-Resistant Acinetobacter baumannii.
Multidrug efflux pumps are a critical mechanism underlying both intrinsic and acquired resistance in Acinetobacter baumannii. One of the most perilous multidrug-resistant (MDR) bacterial infections. Resistance-nodulation-division transporters, including AdeABC, AdeIJK, and AdeFGH, are critical efflux systems that dimin...