Development and Optimization of Matrix-Type Transdermal Patches of Allopurinol for Enhanced Therapeutic Efficacy
Oral allopurinol is widely used to reduce uric acid formation, but development of an alternative sustained-delivery system may help maintain drug release while reducing the need for frequent administration. This study developed matrix-type allopurinol transdermal patches using ethylcellulose (EC) and polyvinylpyrrolido...