Metabolic dysfunction-associated steatotic liver disease, hepatotoxicity, liver fibrosis, and hepatocellular carcinoma are stages of chronic liver injury that occur in the setting of complex interactions of the various factors, including metabolic dysregulation, inflammation, oxidative stress, and cellular senescence....
Amr A. El-Sehrawy, Safa H. Radhie, Mirza R. Baig et al.· Journal of Pharmacology and...· 0 citations
Liver diseases involve major disturbances in iron metabolism, redox homeostasis, and lipid peroxidation; therefore, ferroptosis is considered as an important link between cellular stress and liver damage/progression. This article describes solute carrier family 7 member 11 (SLC7A11), the functional subunit of the cysti...
J. Gupta, Musaab Hamid Farhan, A. Smerat et al.· Tissue & Cell· 0 citations
Myeloproliferative neoplasms (MPN) are shaped by epigenetic rewiring that extends beyond canonical JAK2V617F‐driven signaling. This review argues that context‐dependent chromatin states, not merely genetic lesions, determine disease trajectory, fibrotic transformation, and leukemic progression. We synthesize recent evi...
Amr Ali Mohamed Abdelgawwad El-Sehrawy, M. Al-Khreisat, Aziz Kubaev et al.· Hematological Oncology· 0 citations
Ischemic stroke and subsequent reperfusion injury are major causes of mortality and long-term neurological disability, driven by complex mechanisms of excitotoxicity, oxidative stress, neuroinflammation, endothelial dysfunction, and blood-brain barrier disruption. Increasing evidence indicates that long non-coding RNA...
Amr A. El-Sehrawy, I. Sapaev, O. Nematov et al.· Clinica chimica acta; intern...· 0 citations
The transcriptional coactivators p300 and CREB-binding protein (CBP) integrate chromatin remodeling, enhancer activity, lysine acetylation, immune signaling, and tumor-suppressor control, making them recurrent targets of viral proteins. This narrative review examines p300/CBP at the virus-cancer interface, prioritizing...
A. Atoom, J. Rizaev, D. Polatova et al.· Cancer Treatment and Researc...· 0 citations
Oncolytic virotherapy has evolved from a tumor-selective cytolytic strategy into a programmable immunotherapeutic platform that reshapes the tumor microenvironment (TME). Oncolytic viruses (OVs) selectively infect malignant cells, induce immunogenic cell death, release tumor antigens, and activate innate and adaptive i...
A. Atoom, J. Rizaev, D. Polatova et al.· Cancer Treatment and Researc...· 0 citations
This review aims to examine the emerging roles of OSM in BC, elucidate its multifunctional role in tumor regulation and progression, and ultimately explore therapeutic strategies developed to modulate this cytokine in the context of BC.
Muslem Nuseir, Farrukh Ismatov, A. Abdulqader et al.· IUBMB Life - A Journal of th...· 0 citations
Challenges such as scalable production, cargo heterogeneity, and regulatory considerations remain, but ongoing advances in exosome engineering and patient-derived vesicles are poised to overcome these barriers.
Amr Ali Mohamed Abdelgawwad El-Sehrawy, Hassan Youssef Hussein, O. Nematov et al.· DARU Journal of Pharmaceutic...· 0 citations
This review argues that circular topology should be viewed as an active pharmacologic variable, not merely a stability enhancement, and dissect recent advances in cap-independent translation initiation, including IRES elements and m6A-driven mechanisms, rolling-circle translation for multi-epitope vaccine design, and p...
Amr A. El-Sehrawy, H. Al-Ameer, J. Rizaev et al.· Biotechnology and Bioenginee...· 0 citations
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