Neeraj Patil

Dysregulated MUC5B and MUC5AC impair epithelial barrier function and alter granulocyte frequency and activation in the lung and distal sites.

BACKGROUND Mucus obstructs the airways in respiratory diseases where MUC5B is the major gel-forming mucin in COPD and MUC5AC-rich mucus dominates in asthma. Mucin production changes in response to inflammatory signals, but whether mucin dysregulation drives inflammation is less studied. OBJECTIVE We sought to identif...