Author

Neil R. Fernandes

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Open access Sep 2026

RNASeek: A Cross-Phyla Generative Foundation Model for Multipurpose RNA Modeling and Reinforcement Learning-Based Design

RNA plays central roles in regulating information flow and provides a versatile substrate for engineering biological functions. While large language models (LLMs) have transformed natural language processing and protein design, a general framework connecting RNA foundation models to functional sequence design remains l...

Shi-Yuan Chen, Neil R. Fernandes, Wei Vivian Li et al. · bioRxiv · 0 citations

Open access Aug 2026

Double-stranded DNA donors and CRISPR-Cas9 for universal correction of mutations causing cystic fibrosis in human airway cells

These results demonstrate that low levels of CFTR integration can be made therapeutically relevant by optimizing the designs of gene editing reagents, an essential step toward in vivo gene therapy for CF.

Vrishti Sinha, P. Ayoub, C. Juett et al. · Molecular Therapy: Nucleic A... · 0 citations