Open access
Sep 2026
Investigating the role of a non-synonymous mutation at dhfr codon 50 in maintaining sulphadoxine-pyrimethamine resistance in Plasmodium falciparum: a modelling study.
The study aimed to use empirical data and a mechanistic evolutionary model to explain the pre-discontinuation and post-discontinuation dynamics of SP-resistant P falciparum haplotypes, with a focus on the C50R mutation.
Carola J. Salas, Nessma Adil Mahmoud Yousif, S. Lizewski et al.
· The Lancet Microbe · 0 citations