Enhancers are drivers of gene regulation thought to act via 3D interactions with promoters. However, genome-wide cohesin depletion causes only limited changes in gene expression, despite widespread loss of contact domains, raising questions about how 3D contacts and cohesin influence enhancer function. Here, we intro...
Philine Guckelberger, Benjamin R. Doughty, Suhas S. P. Rao et al.· Nature Communications· 0 citations
Diverse human cell types establish specialized functions through lineage- and context-specific regulatory programs. Interpreting non-coding genetic risk requires integrated multi-omic reference maps that directly connect regulatory DNA to cellular expression across human tissues. Here we present a single-nucleus multi-...
Kai-Li Fan, Amrita Sule, A. Guillaumet-Adkins et al.· bioRxiv· 0 citations
An encyclopedia of enhancer–gene regulatory interactions in the human genome is built, revealing global properties of enhancer networks, identifying differences in regulatory complexity across genes, and improving analyses linking noncoding variants to target genes and cell types for common, complex diseases.
A. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh et al.· Nature· 6 citations
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