Dioscin activates myeloid AMPK to restore Lgr5⁺ stem cell homeostasis and promote mucosal repair in ulcerative colitis.
Ulcerative colitis (UC) is a chronic relapsing inflammatory disease with limited efficacy in achieving durable mucosal healing and preventing dysplasia. Macrophage-intestinal stem cell (ISC) crosstalk plays a central role in epithelial regeneration and tumorigenic transition but remains therapeutically underexplored. H...