A Multifunctional Lasso-like Peptide-Based Electrochemical Biosensor: Overcoming Biofouling and Enzymatic Degradation for High-Fidelity Immunoglobulin G Assay.
The reliable electrochemical detection of immunoglobulin G (IgG) in complex biological fluids is severely hampered by nonspecific protein fouling and enzymatic degradation. Inspired by natural lasso peptides, we engineer a multifunctional lasso-like peptide (LaP) composed entirely of D-amino acids that uniquely integra...