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Author

Niaz Mahmood

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Open access Sep 2026

The 4EHP/GIGYF2 translation repressor complex is co-opted by the vaccinia virus K3L protein as a potential mechanism of immunoevasion.

It is demonstrated that the vaccinia virus-encoded K3L protein interacts with 4EHP via its obligatory binding partner GIGYF2 to increase the stability of the 4EHP/GIGYF2 complex and bolsters 4EHP/GIGYF2-mediated mRNA translation repression.

R. Ladak, A. Pelin, Hao-Tian Zhuang et al. · 0 citations
Review Open access Sep 2026

A therapeutic vulnerability linking MNK1/2 inhibition and G1/S cyclin-dependent kinase blockade in triple-negative breast cancer

It is demonstrated that MNK1/2 inhibition synergizes with CDK4/6 blockade suppresses TNBC cell growth, a synergy also observed in another independent TNBC cell line (SUM159) using a broader G1/S CDK (CDK2/4/6) inhibitor.

Qi-Yun Deng, Mehdi Amiri, A. Moshari et al. · 0 citations

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