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Author

Nicholas Denomme

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Open access Sep 2026

A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective inhibition

SUMMARY We have used small molecule chemical design and protein engineering to fashion an orthogonal ligand-channel pair that enables acute and selective inhibition of a genetically encoded voltage-gated sodium channel (NaV). A modified ligand based on the nerve toxin, saxitoxin (STX), binds potently and reversibly to...

Elizabeth R. Park, Nicholas Denomme, H. Hajare et al. · 0 citations

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