Despite an expanding repertoire of advanced therapies for inflammatory bowel disease (IBD), treatment outcomes remain suboptimal, with only 30%–40% of patients achieving sustained remission. Emerging evidence indicates that therapeutic outcomes are shaped by complex interactions between host immune pathways, the...
John P. Thomas, A. Saifuddin, Sadek Malas et al.· JCC Plus· 0 citations
The gut microbiota, a complex and dynamic community of microorganisms, has emerged as a crucial determinant of human health and well-being in recent years. This microbial ecosystem plays a pivotal role in various physiological processes, including nutrient metabolism, immune system regulation, and intestinal homeostasi...
Anum Javed, Despoina Chrysostomou, J. Marchesi et al.· Inflammatory Bowel Diseases· 0 citations
Ulcerative colitis (UC) is characterised by chronic colonic inflammation with marked heterogeneity in disease severity and therapeutic outcomes. Here, we define a spatially organised, polyfunctional cytotoxic CD4⁺ T-cell state associated with mucosal inflammation and adverse therapeutic outcomes in UC. Integrating ex v...
John P Thomas, S. H. Kottoor, Jonathan W. Lo et al.· bioRxiv· 0 citations
This review synthesizes current mechanistic and translational evidence to conceptualize the gut microbiome as an organ‐like functional system, delineate its structural and functional organization, and propose a framework for mapping, modeling, and therapeutically targeting microbiome‐derived circuits to support precisi...
Yang Bi, Wei-Bin Song, Maria Glymenaki et al.· iMeta· 0 citations
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