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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Nicolas Imstepf

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Open access Sep 2026

Iterative and data-driven ortholog mining enables reliable discovery of stereoselective ketoreductases

Ketoreductases (KREDs) enable stereoselective alcohol synthesis and are widely used industrially. Yet identifying process-compatible and selective enzymes for non-native substrates remains challenging, requiring extensive screening. Here, we present an iterative ortholog mining strategy to explore functional space....

Peter Stockinger, M. Niklaus, Kevin M. Yar et al. · 0 citations

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