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Author

Nicole Beuret

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Open access Sep 2026

A combinatorial pre-mRNP retention factor network couples nuclear speckle architecture to splicing quality control

Cells must prevent incompletely spliced transcripts from entering the cytoplasm, yet how splicing status is recognized and converted into selective nuclear retention remains unclear. Here, we identify a network of RNA-binding proteins that retain pre-mRNPs within nuclear speckles. Proteomic analysis of splicing interme...

K. Dörner, K. Kurth, Nicole Beuret et al. · 0 citations
Open access Aug 2026

PAIP1 couples mRNA export to cytoplasmic mRNP remodeling and poly(A) homeostasis

This work identifies PAIP1 as a metazoan cofactor of the mRNA export ATPase DDX19, and identifies an export-coupled mRNP maturation pathway linking PABP exchange to downstream mRNA metabolism.

D. Overwijn, K. Dörner, Caroline de Almeida et al. · 0 citations

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