Sep 2026
Abstract B068: FYN and other Src family kinases antagonize response to RAS inhibition in pancreatic ductal adenocarcinoma
Oncogenic KRAS drives pancreatic ductal adenocarcinoma (PDAC), yet resistance to RAS antagonists limit benefits. To define therapeutic response and resistance mechanisms, we deployed two complementary preclinical PDAC models, including a degron-regulated KRASG12D-dependent transplantation model, and a Kras G12V-drive...
Hsiu-Chi Ting, Sun Kim, V. Gaeth et al.
· Cancer Research · 0 citations