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Nicole R. West

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Sep 2026

APOE4 astrocytes call the shots on neuronal α-synuclein pathology.

In this issue of Cell Stem Cell, Mesentier-Louro et al. use a multi-cellular integrated brain (miBrain) system to uncover mechanisms underlying the accumulation of neuronal α-synuclein (α-Syn) inclusions in APOE4 carriers.1 Their results suggest that APOE4 increases cholesterol levels and impairs lysosomal function in...

Nicole R. West, Julia Tcw · 0 citations

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