Author

Nicole Santuccio

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Open access Jul 2026

Dopamine D3 receptor blockade restores hippocampal synaptic plasticity and rescues memory deficits in Alzheimer's disease mouse models

Findings demonstrate that D3R-targeting compounds rescue synaptic plasticity and memory deficits in two mechanistically distinct AD models and highlights D3R modulation as a relevant pathway for further investigation in AD-related cognitive impairment.

Maria Rosaria Tropea, Giuseppe Aceto, R. Trovato et al. · Frontiers in Aging Neuroscie... · 0 citations