Nidhi Jalan-Sakrikar

Therapeutic targeting of cancer-associated fibroblasts with oncolytic virus in preclinical models of intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy with limited effective therapies. Treatment resistance is partly due to activated cancer-associated fibroblasts (CAFs), which induce pro-tumor signaling and formation of a highly fibrotic tumor microenvironment. CAFs exist on a functional spectrum of su...