Author

Nien-Pei Tsai

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Open access Oct 2026

Hyperfunction of PSD-95 leads to hyperexcitability and cognitive abnormalities in MEF2C haploinsufficiency.

Myocyte enhancer factor 2C (MEF2C) is a transcription factor critical for brain circuit development and cognitive behavior. The loss of one copy of MEF2C leads to MEF2C haploinsufficiency syndrome (MCHS), a neurodevelopmental disorder characterized by intellectual disability, epilepsy, and behavioral phenotypes associa...

Mei-Jin Pan, Anirudh R. Acharya, Kwan Lee et al. · Proceedings of the National... · 0 citations

Open access Aug 2026

Spatially varying gene regulation network inference from spatial transcriptomics

Applications to seqFISH mouse embryo data and Visium human cutaneous squamous cell carcinoma and fallopian tube datasets demonstrate that SVGRN captures spatially varying regulatory programs underlying development, tumor progression, and tissue organization, highlighting its robustness and broad applicability.

Yu-Rui Li, Jin Y. Chen, Ting Lu et al. · Bioinformatics Advances · 0 citations