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Nikita H. Amin

2 papers indexed here

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Open access Oct 2026

Rationally tailored antibiotic selection circumvents toxin-mediated evasion of killing in Mycobacterium abscessus

Among clinically important non-tuberculous mycobacteria, Mycobacterium abscessus (Mab) has a large and highly dynamic accessory genome within an open pangenome, contributing traits that enhance drug resistance, bacterial persistence, stress survival, metabolic flexibility, and/or virulence. Defining how accessory l...

Nikita H. Amin, E. Troian, N. Woychik · 0 citations
Open access Oct 2026

Acquisition of a toxin-antitoxin system within a mobile genetic element likely enhances Mycobacterium abscessus fitness by enforcing cargo retention

The findings uncover the mechanism for durable expansion of the Mab accessory genome and suggest a selective advantage whereby toxin-mediated entry into a reversible growth-arrested state may reduce antibiotic susceptibility.

Nikita H. Amin, E. Troian, Heather M. Maldonado et al. · 0 citations

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