Computational Design and Evaluation of Modified AEW-1 Chalcone Derivatives as Potential Anti-Inflammatory Agents
Long-term therapy of inflammation is limited by gastrointestinal, cardiovascular, and renal side effects, motivating the search for safer, multi-target anti-inflammatory agents. The chalcone derivative AEW-1, which exhibits in vivo anti-inflammatory activity comparable to ibuprofen, was selected for rational optimizati...