Spatial Proteomics and Epigenomics Reveal Cell Morphology and Epigenetic Gene Regulation in Human Hippocampus
Abstract We present the first spatial tri-omic (proteomic, transcriptomic, and epigenomic) taxonomy of human hippocampus, addressing two key challenges in single-cell and spatial transcriptomics: visualizing cell morphology and epigenetic gene regulation in situ. By designing and multiplex imaging a novel panel of 25 p...