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Nina Dashti-Gibson

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Open access Sep 2026

Liver disease reveals KIF12 as a regulator of mitochondria, lysosome and cilia localisation in human cholangiocytes

Summary Background Rare bi-allelic mutations in kinesin family member 12 (KIF12) cause high gamma-glutamyl transferase (GGT) cholestatic liver disease, yet the cellular mechanisms driving this phenotype remain unknown. Methods To investigate the role of KIF12 in biliary pathology, we introduced the homozygous p.Arg219∗...

Anubha Seth, Joseph Brancale, Nina Dashti-Gibson et al. · 0 citations

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