Oct 2026
HMGA2 Expression in Pancreatic Ductal Adenocarcinoma Controls Tumor Microenvironment and Immunosuppression via IL1α
Naomi Yamamoto, S. Dobersch, Tess M. Robertson et al.
· bioRxiv · 0 citations
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Open access
Sep 2026
Comparative Analysis of Primary and Liver Fibroblasts Reveals MET as a Potent Target in Pancreatic Cancer Metastasis.
BACKGROUND AND AIMS The tumor microenvironment drives many malignant features of pancreatic ductal adenocarcinoma (PDAC). The fibroblasts within pancreatic tumors promote tissue remodeling, immune suppression, and resistance to therapy. However, the interactions between stromal populations and pancreatic cancer cells a...
Rima Singh, Natalie Yousefian, Walker M. Allen et al.
· Cellular and Molecular Gastr... · 0 citations
Sep 2026
Abstract B011: HMGA2 controls fibroblast skewing and immune infiltration in basal pancreatic cancer
The role of tumoral HMGA2 expression in controlling an immunosuppressive TME is demonstrated, a potential biomarker to determine TME phenotype in PDAC patients is highlighted and a novel subtype-specific immunomodulatory therapy is introduced.
Naomi Yamamoto, S. Dobersch, Tess M. Robertson et al.
· Cancer Research · 0 citations