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Ning-Kui Niu

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Open access Sep 2026

IgE drives osteoclastogenesis via binding with FcεRII in sparganosis-induced bone destruction

Progressive multi-vertebral osteolysis, frequently misdiagnosed as malignancy or tuberculosis, can also be driven by a previously unrecognized infectious trigger. Here we demonstrate that sparganosis induces pronounced IgE-dependent osteoclastogenesis and severe bone destruction. Single-cell RNA analysis of periphera...

Yong-Ai Li, T. Meng, Ying-Qi Wang et al. · 0 citations
Review Open access Aug 2026

Vγ9Vδ2 T cells in tuberculosis: protective immunity and translational perspectives

Emerging evidence for Vγ9Vδ2 T cell immunological memory provides a rationale for novel vaccine strategies, although the translatability of these findings to human TB remains to be established.

Zhi-Yun Shi, Yixin Ding, X. Jing et al. · 0 citations
Review Open access Aug 2026

Integrated histopathology and single-cell transcriptomics reveal distinct pathological features and foamy macrophage characteristics in spinal tuberculosis and brucellar spondylitis

Histopathological comparison showed that STB and BS were both dominated by chronic inflammation but exhibited distinct lesion patterns, and Macro4 is best interpreted as a BS-associated lipid-remodelled macrophage state supported by convergent histological and transcriptomic evidence.

Qiang Liu, Han-Hua Guo, Jun-Xiao Liu et al. · 0 citations
Review Open access Jul 2026

Deep learning segmentation with uncertainty quantification for spinal tuberculosis on fat-suppressed T2-weighted MRI

An uncertainty-guided deep learning segmentation framework improved spinal tuberculosis lesion segmentation accuracy and enhanced clinician trust, offering a robust AI decision-support tool for precise surgical planning.

Xing-Yu Duan, Jia-Xing Wang, Li-Nan Wang et al. · 0 citations

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