Summary Coxsackievirus B1 (CVB1), a clinically significant human enterovirus, causes a wide spectrum of diseases ranging from mild illness to severe, life-threatening conditions in susceptible individuals. However, investigations into CVB1 infection pathogenesis, as well as the development and evaluation of antiviral s...
Chang-Jian Fang, Kang Yu, Jia Xue et al.· iScience· 0 citations
Severe pneumonia caused by respiratory virus infection is one of the main threats to the lifespan of the aged population and physiological aging fundamentally drives poor disease outcomes in respiratory viral infections, necessitating investigation of the underlying mechanisms and the development of effective counterme...
Ming Zhou, Xuan Liu, Jinxin Miao et al.· Molecular Biomedicine· 0 citations
The continued evolution of SARS-CoV-2 has reduced the protective effectiveness of first-generation vaccines and underscores the need for broadly reactive next-generation vaccine candidates. Here, we evaluated STFKB, an alum-adjuvanted bivalent recombinant protein vaccine composed of the monomeric Spike (STFKprototype)...
Zi-Kang Wang, Jia-Hua Gao, Ru Bai et al.· Viruses· 0 citations
It is demonstrated that a rational combination of pharmacological targeting of innate and adaptive immune responses is sufficient to reduce mortality and severe illness caused by beta, delta and EG.1 variants in SARS-CoV-2 infection.
Ming Zhou, Xuan Liu, Haiqing Xiao et al.· Molecular Therapy· 0 citations
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