Author

Nirvana A. Gohar

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Open access Aug 2026

Discovery of New Pyrazole‐Linked Pyridine Derivatives as Multi‐Target Anti‐Inflammatory Agents With Immunomodulatory Potential

Cyclooxygenase (COX) plays a crucial role in the inflammatory response, making selective COX‐2 inhibition a significant strategy for developing safer anti‐inflammatory medications. Accordingly, developing new pharmacotherapies is a critical objective in anti‐inflammatory drug discovery. In this study, a new pyrazole‐li...

Mohamed A. Salem, Reham R Raslan, Nirvana A. Gohar et al. · Drug development research (P... · 0 citations

Sep 2026

Cyanopyridine-based derivatives as potent anticancer agents: Integrating in silico analysis and in vitro biological targeting of the EGFR/AKT/MAPK Signaling Cascade.

The increasing global incidence of cancer and the recurrent development of resistance to standard treatments require a rapid development of innovative, multi-targeted chemotherapeutic medicines. This study focused on the strategic design and synthesis of a range of new cyanopyridine derivatives (1a,b-5a,b) targeting th...

Shimaa M. Alhamaky, Marwa S. A. Hassan, Eman M. Ahmed et al. · Bioorganic chemistry (Print) · 0 citations

Jul 2026

Insights into novel benzo[h]quinoline-based 2-thioxothiazolidin-4-one and thiazol-4-one hybrids as potential antimicrobial, and antibiofilm candidates: Design, synthesis, molecular modeling, and in-silico ADME studies.

The findings strongly confirm the substituted benzo[h]quinoline core as a highly promising pharmacophore for the development of next-generation antimicrobial medicines effective against both free-floating planktonic cells and tough structured biofilms.

Reham R Raslan, S. Eissa, Moustafa S. Abusaif et al. · Bioorganic chemistry (Print) · 0 citations