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Beyond task performance, PHASE learns to encapsulate the physiological characteristics clinicians recognize, from seizure onset and its propagation to anatomical region identity, even though its pretraining contains no ictal recordings or anatomical labels.
Structural connectivity partially mediates the seizure-survival association, suggesting preserved network architecture may contribute to why seizure patients survive longer, though the majority of the effect operates through other pathways.
Using multi-shell dMRI, whole-brain variability and covariability across 26 dMRI statistics derived from five reconstruction models are quantified, and a framework for concise dMRI metric selection for comprehensive microstructural investigations is supported.
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