Author

Nitya Nair

2 papers indexed here

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Open access Sep 2026

Multimodal characterization of HLA-G expression across solid tumors reveals transcript-protein discordance and implications for immunotherapy targeting

Introduction Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class I molecule that functions as an immune checkpoint via inhibitory receptors such as immunoglobulin-like transcript 2 (ILT2), immunoglobulin-like transcript 4 (ILT4) and killer cell immunoglobulin-like receptor 2DL4 (...

Alexandra Epp, M. Serrano-Serrano, Florian Heil et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Early functional reactivity to a CEACAM5 x CD3 T cell bispecific antibody in solid tumors associates with baseline immune contexture rather than target antigen density alone

Clinical translation of T cell bispecific (TCB) therapies in solid tumors is hindered by the immunosuppressive tumor microenvironment and intratumoral heterogeneity, features poorly captured by standard preclinical models. We applied an integrated translational framework, combining humanized mouse models, a patient-d...

Sabine Wilson, Abraham Silva, M. Serrano-Serrano et al. · npj Precision Oncology · 0 citations