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Author

Nobuhiro Nishiyama

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Open access Oct 2026

Dual-State Tumor-Activated RNA Delivery for Tumor-Selective and Precision Therapy.

RNA therapeutics hold transformative potential for precision oncology; however, their systemic application remains constrained by a fundamental tradeoff between prolonged circulation stability and efficient intracellular activation. Conventional polyethylene glycol (PEG)-based carriers provide antifouling protection bu...

Yuan-Shuai Song, Tian Jiang, Xin Shen et al. · 0 citations
Open access Oct 2026

Polymer-photosensitizer conjugate exerting pH-responsive hydrophilic-to-hydrophobic conversion for cell-specific photochemical internalization of mRNA.

Cell-specific intracellular delivery of messenger RNA (mRNA) remains a challenge in the development of RNA therapeutics. Photochemical internalization (PCI) is a useful technology for the spatially controllable cytosolic delivery of such molecules in a light-selective manner, but cellular-level precision has yet to be...

Daiki Tokura, Yi-Ming Xia, Han-Qing Jiang et al. · 0 citations

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