Author

Noemi Gatto

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Open access Sep 2026

Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by the death of motor neurons leading to paralysis and death generally 3–5 years post-symptom onset. ALS is a cell- and non-cell-autonomous disease, with glia such as astrocytes influencing disease pathology and progression. Our laboratory...

Benjamin J. Hall, Yasmina M. Ebrahim, Joanne L. Sharpe et al. · International Journal of Mol... · 0 citations

Open access Jul 2026

Glycogen-Dependent Metabolic Reprogramming Regulates Microglial Activation and Dysfunction in Neurodegenerative Disease

Glycolytic inhibition of glycogenolysis blunted microglia responses to Abeta aggregates and markedly reduced Abeta uptake, confirming a functional role for glycogen metabolism in shaping microglial states and highlighting glycogen homeostasis as a potential therapeutic target for promoting Abeta clearance and preservin...

Hannah McAlister, Heather Merchant, Verity F. T. Mitchener et al. · bioRxiv · 0 citations