Noor Waleed

Computationally Guided Design of New Naphthalene-Oxazole-Hydrazone Derivatives as Potential HDAC Inhibitors: ADME Assessment, Molecular Docking, Molecular Dynamics, and MM/GBSA Analysis

Histone deacetylases (HDACs) are important therapeutic targets in cancer because of their central role in epigenetic regulation. Although several hydroxamate-based HDAC inhibitors have reached clinical use, their limited selectivity and unfavourable pharmacokinetic properties have encouraged the development of alternat...