Open access
Aug 2026
SARS-CoV-2 Orf3a protein interaction mapping using unnatural amino acid incorporation
It is demonstrated that genetically encoded, site-specific photo-crosslinking enables selective capture of transient interactions that are often missed by nonspecific 254 nm UV crosslinking approaches and highlights Orf3a as a multifunctional protein that engages diverse host pathways.
Eryn Lundrigan, Noreen Ahmed, J. P. Pezacki
· Protein engineering, design... · 0 citations