Author

O. Coman

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Review Open access Sep 2026

Biosensing Platforms and Multimodal Monitoring of Sepsis-Associated Cell Death

Apoptosis plays an important role in sepsis-associated immune dysfunction, particularly through lymphocyte depletion and the development of persistent immunosuppression. This review examines apoptosis-associated biomarkers in sepsis, distinguishing relatively direct markers of cell death from complementary indicators o...

O. Coman, L. Azamfirei, Oana Frandeș et al. · Biosensors · 0 citations

Open access Jul 2026

Differential Effects of Donepezil and Tacrine on Recall-Phase Exploratory Behavior in Healthy Male Wistar Rats: A Two-Trial Y-Maze Study

Cholinesterase inhibitors with distinct pharmacological profiles may influence exploratory behavior, yet their effects on recall-related exploration in physiologically intact animals remain insufficiently characterized. The present study aimed to directly compare the effects of donepezil, a relatively selective acetylc...

Adrian-Florentin Dragomir, S. Stoleru, A. Barbu et al. · Biomolecules · 0 citations

Open access Aug 2026

Differential Dose–Response Behavioural Profiles of Diazepam, Zolpidem and Indiplon in a Two-Trial Y-Maze Paradigm in Rats

Background: Benzodiazepines and non-benzodiazepine hypnotics (Z-drugs) act at the benzodiazepine binding site of GABAA receptors but differ in their receptor subtype selectivity and behavioural profiles. Diazepam acts as a non-selective positive allosteric modulator of benzodiazepine-sensitive GABAA receptors, whereas...

M. V. Moraru, O. Coman, A. Zugravu et al. · Pharmaceuticals · 0 citations